منابع مشابه
Subgroup analyses in Orgalutran trials.
I read with interest the European–Middle East Orgalutran trial (The European Orgalutran Study Group et al., 2000) and I noticed that the study extensively monitored hormonal assays (LH, FSH, oestradiol). It is well known that sufficient stimulation of both theca cells and granulosa cells by LH and FSH is required for adequate oestradiol biosynthesis (Short, 1962; Schoot et al., 1992) and hence ...
متن کاملConsiderations on Subgroup Analyses in Clinical Trials.
As clinicians, we routinely treat patients with drugs whose efficacy is supported by evidence from multicenter clinical trials, some of which include thousands of patients from different parts of the world. When it comes to treating a given patient, however, we need to know whether the beneficial effect described for the average patient will apply to this patient in particular. This can be done...
متن کاملStatistics in medicine--reporting of subgroup analyses in clinical trials.
Medical research relies on clinical trials to assess therapeutic benefits. Because of the effort and cost involved in these studies, investigators frequently use analyses of subgroups of study participants to extract as much information as possible. Such analyses, which assess the heterogeneity of treatment effects in subgroups of patients, may provide useful information for the care of patient...
متن کاملSubgroup Analyses in Reporting of Phase III Clinical Trials in Solid Tumors.
PURPOSE Treatment decisions in clinical oncology are guided by results from phase III randomized clinical trials (RCTs). The results of subgroup analyses may be potentially important in individualizing patient care. We investigated the appropriateness of the use and interpretation of subgroup analyses in oncology RCTs on the basis of the CONSORT statement requirements. METHODS Phase III RCTs ...
متن کاملSubgroup analyses in randomised controlled trials: quantifying the risks of false-positives and false-negatives.
BACKGROUND Subgroup analyses are common in randomised controlled trials (RCTs). There are many easily accessible guidelines on the selection and analysis of subgroups but the key messages do not seem to be universally accepted and inappropriate analyses continue to appear in the literature. This has potentially serious implications because erroneous identification of differential subgroup effec...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2001
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/16.12.2726-a